Dogs only need one general anti-viral vaccine ( Parvo, Distemper, etc. )  to be protected for life. This Vaccine should occur between 7-15 weeks of age.  Then one Rabies vaccine between 8-12 months of age.  Beginning with the second Vaccine of either, Vaccinosis begins to manifest itself. Vaccinosis has the same effect on dogs as does ” Lupus ” in humans. It is actually the same condition with different causes. After Vaccinosis is established, Autoantibodies  begin to ravage a dogs body causing vast organ and tissue damage. Such damage then allows disease to manifest itself.  Along with spaying and neutering, such is why modern dogs in America are ravaged with Cancers and organ problems.